Objective
To utilize my skills and experience in computational structural biology, protein and antibody engineering and optimization, and team based therapeutic development to aid in the discovery of cures for and treatment of illness and disease.
Interests
Engineering biologics-based therapeutics, inventing novel therapeutic modalities and computational methods for therapeutic design, and computational and experimental approaches to understanding and controlling biophysical properties of biological macromolecules. Research direction focused on computational structural biology while also applying skills to broader platform review and direction. Working in areas of antibody design, epitope mapping, molecular assessment, stability engineering, construct design, protein structure analysis, protein engineering, and working with therapeutic area teams to lead target development.
- Computational structural biology
- Antibody design
- Protein stability engineering
- Therapeutic development
- Protein structure analysis
- Expert user of the Molecular Operating Environment
- Project team environments
- Computational and experimental approaches to understanding and controlling biophysical properties of biological macromolecules
Just Biotherapeutics
In 2014 a small group of scientific leaders in biotherapeutic development came together to enable the vision to "Design and apply innovative technologies to dramatically expand global access to biotherapeutics." We knew that to accomplish this mission we would have to innovate across the entire biotherapeutic discovery, design, process development, and manufacturing space. We had the shared experience of the complexity and cost of delivering biotherapeutics and knew that we could have a strong impact, opening broader markets for these life-changing therapies. We worked together in a highly collaborative team to build solutions such as AI-driven antibody discovery, antibody modality design methods, in silico and empirical antibody developability analyses, sequence optimizations, data capture and workflows across functional areas, democratized data for cross-functional applications, data and laboratory automation to increase throughput, continuous perfusion production, and much more. My role as a Senior Vice President was to:
- Coordinate development of and utilize our proprietary Abacus antibody analysis and design platform
- Evaluate and ensure historical learning from empirical characterization data
- Build a software engineering team to enable data capture, workflows, and data automation
- Build a data science team to implement data analyses, ML/AI methods, and data governance across functions
- Build an antibody discovery team to implement our AI-driven discovery platform with both Fab and VHH
- Build an antibody engineering team for analyses, optimization design, humanization, rational affinity design, structure modeling, and more
Since the inception of Just we have accomplished so much more than the impossible goals we had set for ourselves.
Publications
Peer Reviewed
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Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor-Binding Enhancement
Journal of Pharmacology and Experimental Therapeutics. 2015
https://doi.org/10.1124/jpet.114.221242
PDF of paper
Invited
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High Resolution Polypeptide Structure in Anisotropic Environments: The Gramicidin Channel
Proceedings of the Conference on Stable Isotope Applications in Biomolecular Structure and Mechanisms, 1994 -
Structure and Dynamics of a Membrane Bound Polypeptide
Bulletin of Magnetic Resonance v14, 96-101, 1993
PDF of paperPatents
Patents Issued
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Implementing A Generative Machine Learning Architecture To Produce Training Data For A Classification
Model
Filed: 2021-08-27
Issued: 2024-09-03
Inventors: Shaver, Jeremy Martin; Amimeur, Tileli; Ketchem, Randal Robert; Smith, Joshua
United States Patent: US 12080380 B2
PDF of issued patent.
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Human IL-23 antigen binding proteins
Filed: 2021-11-12
Issued: 2024-06-18
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent: US 12012449 B2
PDF of issued patent.
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Human IL-23 antigen binding proteins
Filed: 2016-09-21
Issued: 2018-04-24
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent: US 9951129 B2
PDF of issued patent.
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Human IL-23 antigen binding proteins
Filed: 2014-03-28
Issued: 2016-11-08
Inventors: Towne, Jennifer E., Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent: US 9487580 B2
PDF of issued patent.
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Human IL-23 antigen binding proteins
Filed: 2010-09-09
Issued: 2014-05-13
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent: US 8722033 B2
PDF of issued patent.
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Determining Conditions for Purification of Proteins
Filing Date: 2019-02-21
Publication Date: 2024-03-06
Inventors: Shaver, Jeremy, Martin; Amimeur, Tileli; Gillespie, Ron; Ketchem, Randal, R.; Garcia, Fernando
WIPO Patent: EP 3 755 447 B1
PDF of issued patent.
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Interleukin-2 Muteins For The Expansion Of T-regulatory Cells
Filing Date: 2020-10-07
Publication Date: 2024-05-07
Inventors: Butz, Eric Alan; Thomson, Christy Ann; Gavin, Marc Alain; Foltz, Ian Nevin; Xia, Dong; Alcorn, Dina N.; Ketchem, Randal Robert; Lim, Ai Ching; Manchulenko, Kathy; Sekirov, Laura; Berry, Kelly Ann; De Imus, Cyr Clovis Chua; Agrawal, Neeraj Jagdish; Kannan, Gunasekaran; Li, Li
United States Patent: US 11976103 B2
PDF of issued patent.
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ST2 Antigen Binding Proteins
Filing Date: 2021-06-04
Publication Date: 2024-04-23
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent: US 11965029 B2
PDF of issued patent.
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Autoencoder With Generative Adversarial Network To Generate Protein Sequences
Filing Date: 2021-09-21
Publication Date: 2024-04-02
Inventors: Shaver, Jeremy Martin; Amimeur, Tileli; Ketchem, Randal Robert
United States Patent: US 11948664 B2
PDF of issued patent.
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Antibody Therapies For Human Immunodeficiency Virus (HIV)
Filed: 2019-05-22
Issued: 2023-12-19
Inventors: Barouch, Dan H.; Kerwin, Bruce A.; Ketchem, Randal R.; Gillespie, Alison J.; Siska, Christine C.; Clark, Rutilio H.; Floyd, Julee A.; Shaver, Jeremy M.; Rogers, Richard S.
United States Patent: US 11804283 B2
PDF of issued patent.
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Predicting Molecular Properties Of Molecular Variants Using Residue-specific Molecular Structural
Features
Filed: 2018-06-08
Issued: 2023-10-31
Inventors: Shaver, Jeremy Martin; Ketchem; Randal Robert
United States Patent: US 11804283 B2
PDF of issued patent.
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Anti-CSP Antibodies
Filed: 2020-06-16
Issued: 2023-05-23
Inventors: Emerling, Daniel Eric; Ketchem, Randal R.; Lippow, Shaun M.; Volkmuth, Wayne; Williams, Katherine L.
United States Patent: US 11655290 B2
PDF of issued patent.
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Generation Of Protein Sequences Using Machine Learning Techniques
Filed: 2020-05-19
Issued: 2023-02-21
Inventors: Amimeur, Tileli; Ketchem, Randal Robert; Shaver, Jeremy Martin; Clark, Rutilio H.; Taylor, John Alex
United States Patent: US 11587645 B2
PDF of issued patent.
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Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
Filed: 2014-09-05
Issued: 2022-08-30
Inventors: Du, Zhimei; Reddy, Pranhitha; Bass, Randal B.; He, Feng; Fanslow, III, William C.; Zhang, Yuling; Ren, Da; Ketchem, Randal R.
United States Patent: US 11427627 B2
PDF of issued patent.
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Direct selection of cells expressing high levels of heteromeric proteins using glutamine synthetase
intragenic complementation vectors
Filed: 2017-05-11
Issued: 2022-07-12
Inventors: Ketchem, Randal Robert; McGrew, Jeffrey T.; Fomina Yadlin, Dina A.
United States Patent: US 11384140 B2
PDF of issued patent.
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Variants of tissue inhibitor or metalloprotienase type three (TIMP-3), compositions and methods
Filed: 2015-08-26
Issued: 2021-10-19
Inventors: O'Neill, Jason C.; Ketchem, Randal R.; Lee, Taeweon; Chintalgattu, Vishnu; Stevens, Jennitte Leann
United States Patent: US 11149078 B2
PDF of issued patent.
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ST2 antigen binding proteins
Filed: 2019-01-08
Issued: 2021-07-13
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent: US 11059895 B2
PDF of issued patent.
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ST2 antigen binding proteins
Filed: 2017-05-22
Issued: 2019-03-12
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent: US 10227414 B2
PDF of issued patent.
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ST2 antigen binding proteins
Filed: 2016-06-10
Issued: 2018-05-29
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent: US 9982054 B2
PDF of issued patent.
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ST2 antigen binding proteins
Filed: 2013-05-17
Issued: 2016-07-05
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent: US 9382318 B2
PDF of issued patent.
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Interleukin-2 Muteins For The Expansion Of T-regulatory Cells
Filed: 2016-05-04
Issued: 2020-12-01
Inventors: Butz, Eric Alan; Thomson, Christy Ann; Gavin, Marc Alain; Foltz, Ian Nevin; Xia, Dong; Alcorn, Dina N.; Lim, Ai Ching; Ketchem, Randal Robert; Manchulenko, Kathy; Sekirov, Laura; Berry, Kelly Ann; De Imus, Cyr Clovis Chua; Agrawal, Neeraj Jagdish; Kannan, Gunasekaran; Li, Li
United States Patent: US US 10851144 B2
PDF of issued patent.
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Variants of tissue inhibitor of metalloproteinase type three (TIMP-3), compositions and methods
Filed: 2014-03-13
Issued: 2019-01-29
Inventors: Sun, Jeonghoon; O'Neill, Jason Charles; Ketchem, Randal R.; Hecht, Randy Ira; Belouski, Edward J.; Michaels, Mark Leo
United States Patent: US 10189890 B2
PDF of issued patent.
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Monoclonal antibodies to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2011-06-30
Issued: 2018-03-20
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terrence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent: US 9920134 B2
PDF of issued patent.
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Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-08-14
Issued: 2016-11-15
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 9493576 B2
PDF of issued patent.
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Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-08-14
Issued: 2015-06-16
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 9056915 B2
PDF of issued patent.
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Methods of using antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2011-10-03
Issued: 2015-06-02
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 9045547 B2
PDF of issued patent.
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Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-08-14
Issued: 2015-03-17
Inventors: Jackson, Simon Mark; Shan, Bei; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8981064 B2
PDF of issued patent.
-
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-04-24
Issued: 2014-11-18
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8889834 B2
PDF of issued patent.
-
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-04-24
Issued: 2014-11-11
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8883983 B2
PDF of issued patent.
-
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-04-24
Issued: 2014-10-28
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8871913 B2
PDF of issued patent.
-
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-04-24
Issued: 2014-10-28
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8871914 B2
PDF of issued patent.
-
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2014-04-24
Issued: 2014-10-14
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8859741 B2
PDF of issued patent.
-
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2013-04-10
Issued: 2014-09-09
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8829165 B2
PDF of issued patent.
-
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Filed: 2009-05-28
Issued: 2013-10-22
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent: US 8563698 B2
PDF of issued patent.
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Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor
Filed: 2012-12-17
Issued: 2017-06-27
Inventors: Sun, Jeonghoon; Han, Seog Joon; Harris, Susie M; Ketchem, Randal R; Lu, Ji; Michaels, Mark L; Retter, Marc W; Tsai, Mei-Mei
United States Patent: US 9688756 B2
PDF of issued patent.
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GITR antigen binding proteins and methods of use thereof
Filed: 2014-08-28
Issued: 2016-10-11
Inventors: Beers, Courtney; O'Neill, Jason C.; Foltz, Ian; Ketchem, Randal R.; Piasecki, Julia C.
United States Patent: US 9464139 B2
PDF of issued patent.
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Anti-hepcidin antibodies and methods of use
Filed: 2009-04-28
Issued: 2016-04-19
Inventors: Foltz, Ian; Gallo, Michael; Cooke, Keegan; Ketchem, Randal R.; Mehlin, Christopher
United States Patent: US 9315577 B2
PDF of issued patent.
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IL-1F8 polypeptides
Filed: 2013-06-11
Issued: 2014-10-28
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
United States Patent: US 8871192 B2
PDF of issued patent.
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IL-1F5 Polypeptides
Filed: 2011-09-02
Issued: 2013-07-09
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
United States Patent: US 8481021 B2
PDF of issued patent.
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IL-1F6 Polypeptides
Filed: 2007-09-10
Issued: 2011-10-11
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
United States Patent: US 8034771 B2
PDF of issued patent.
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Tweak receptor
Filed: 2010-10-06
Issued: 2013-04-09
Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.
United States Patent: US 8414895 B2
PDF of issued patent.
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TWEAK receptor
Filed: 2009-01-16
Issued: 2010-11-09
Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.
United States Patent: US 7829675 B2
PDF of issued patent.
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TWEAK receptor
Filed: 2005-09-22
Issued: 2009-02-24
Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III
United States Patent: US 7495086 B2
PDF of issued patent.
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TRAIL Receptor-2 Polypeptides and antibodies
Filed: 2007-08-02
Issued: 2009-04-21
Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
United States Patent: US 7521048 B2
PDF of issued patent.
Patents Published
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RESIDUAL ARTIFICIAL NEURAL NETWORK TO GENERATE PROTEIN SEQUENCES
Filing Date: 2022-08-31
Publication Date: 2024-12-05
Inventors: Smith, Joshua; Shaver, Jeremy Martin; Amimeur, Tileli; Ketchem, Randal Robert; Taylor, John Alex
United States Patent Application: US 20240404634 A1
PDF of patent application.
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CD8-SPECIFIC BINDING PROTEINS AND METHODS OF USING THE SAME
Filing Date: 2024-05-23
Publication Date: 2024-11-28
Inventors: JULIEN, Susan; CRANE, Courtney; SWIDEREK, Kristine; THERRIAULT, Jon, H.; MEENGS, Brent; AHMED, Lucky; D'ANGELO, Igor; KETCHEM, Randal, Robert; JEPSON, Sofia. Zaiga; SMIDT, Pauline, S.; SISKA, Christine, C.; CALVILLO, Sarah, Jane; BASLER, Eleanor DeGenova; JUMPA, Taylor
WIPO Patent Application: WO/2024/243423
PDF of patent application.
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ST2 ANTIGEN BINDING PROTEINS
Filing Date: 2024-03-20
Publication Date: 2024-11-07
Inventors: SMITH, Dirk E.; FOLTZ, Ian; KING, Chadwick T.; LIM, Ai Ching; CLARK, Rutilio; COMEAU, Michael R.; KETCHEM, Randal R.; SHI, Donghui; MIN, Xiaoshan; WANG, Zhulun
United States Patent Application: US 20240368292 A1
PDF of patent application.
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INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
Filing Date: 2024-04-05
Publication Date: 2024-10-03
Inventors: BUTZ, Eric Alan; THOMSON, Christy Ann; GAVIN, Marc Alain; FOLTZ, Ian Nevin; XIA, Dong; ALCORN, Dina N.; KETCHEM, Randal Robert; LIM, Ai Ching; MANCHULENKO, Kathy; SEKIROV, Laura; BERRY, Kelly Ann; DE IMUS, Cyr Clovis Chua; AGRAWAL, Neeraj Jagdish; KANNAN, Gunasekaran; LI, Li
United States Patent Application: US 20240327486 A1
PDF of patent application.
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MACHINE LEARNING ARCHITECTURE TO GENERATE PROTEIN SEQUENCES
Filing Date: 2023-10-04
Publication Date: 2024-04-11
Inventors: AMIMEUR, Tileli; SHAVER, Jeremy Martin; KETCHEM, Randal Robert; TAYLOR, Alex; CLARK, Rutilio H.
WIPO Patent Application: WO/2024/076641
PDF of patent application.
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VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
Filing Date: 2021-09-21
Publication Date: 2024-01-11
Inventors: Sun, Jeonghoon; O'Neill, Jason Charles; Ketchem, Randal R.; Hecht, Randy Ira; Belouski, Edward J.; Michaels, Mark Leo
United States Patent Application: US 20240010708 A1
PDF of patent application.
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AUTOENCODER WITH GENERATIVE ADVERSARIAL NETWORK TO GENERATE PROTEIN SEQUENCES
Filing Date: 2021-09-21
Publication Date: 2023-10-19
Inventors: Shaver, Jeremy Martin; Amimeur, Tileli; Ketchem, Randal Robert
United States Patent Application: US 20230335222 A1
PDF of patent application.
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IMPLEMENTING A GENERATIVE MACHINE LEARNING ARCHITECTURE TO PRODUCE TRAINING DATA FOR A CLASSIFICATION
MODEL
Filing Date: 2021-08-27
Publication Date: 2023-08-10
Inventors: Shaver, Jeremy Martin; Amimeur, Tileli; Ketchem, Randal Robert; Smith, Joshua
United States Patent Application: US 20230253067 A1
PDF of patent application.
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Fc-Containing Molecules Exhibiting Predictable, Consistent, And Reproducible Glycoform Profiles
Filing Date: 2022-07-14
Publication Date: 2023-07-27
Inventors: DU, Zhimei; REDDY, Pranhitha; BASS, Randal B.; HE, Feng; FANSLOW, III, William C.; ZHANG, Yuling; REN, Da; KETCHEM, Randal R.
United States Patent Application: US 20230235024 A1
PDF of patent application.
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FC-CONTAINING MOLECULES EXHIBITING PREDICTABLE, CONSISTENT, AND REPRODUCIBLE GLYCOFORM PROFILES
Filing Date: 2014-09-05
Publication Date: 2016-07-21
Inventors: Du, Zhimei; Reddy, Pranhitha; Bass, Randal B.; He, Feng; Fanslow, III, William C.; Zhang, Yuling; Ren, Da; Ketchem, Randal R.
United States Patent Application: 20160207980
PDF of patent application.
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ANTI-CSP ANTIBODIES
Filing Date: 2023-01-26
Publication Date: 2023-06-01
Inventors: Emerling, Daniel Eric; Ketchem, Randal R.; Lippow, Shaun M.; Volkmuth, Wayne; Williams, Katherine L.
United States Patent Application: US 20230167169 A1
PDF of patent application.
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ANTI-CSP ANTIBODIES
Filing Date: 2022-06-16
Publication Date: 2023-01-05
Inventors: Emerling, Daniel Eric; Ketchem, Randal R.; Lippow, Shaun M.; Volkmuth, Wayne; Williams, Katherine L.
United States Patent Application: US 20230002483 A1
PDF of patent application.
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GENERATING PROTEIN SEQUENCES USING MACHINE LEARNING TECHNIQUES BASED ON TEMPLATE PROTEIN SEQUENCES
Filing Date: 2020-12-11
Publication Date: 2023-01-05
Inventors: SHAVER, Jeremy Martin; AMIMEUR, Tileli; KETCHEM, Randal Robert; TAYLOR, Alex
United States Patent Application: US 20230005567 A1
PDF of patent application.
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FACILITIES AND PROCESSES TO PRODUCE BIOTHERAPEUTICS
Filing Date: 2020-02-14
Publication Date: 2022-08-11
Inventors: Shaver, Jeremy Martin; Amimeur, Tileli; Ketchem, Randal Robert; Vandiver, Michael W.; Horman, Brian W.; Garcia, Fernando
United States Patent Application: 20220251498
PDF of patent application.
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GENERATION OF PROTEIN SEQUENCES USING MACHINE LEARNING TECHNIQUES
Filing Date: 2023-01-13
Publication Date: 2023-06-08
Inventors: Amimeur, Tileli; Ketchem, Randal Robert; Shaver, Jeremy Martin; Clark, Rutilio H.; Taylor, John Alex
United States Patent Application: US 20230178186 A1
PDF of patent application.
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GENERATION OF PROTEIN SEQUENCES USING MACHINE LEARNING TECHNIQUES
Filing Date: 2020-05-19
Publication Date: 2022-07-21
Inventors: AMIMEUR, Tileli; KETCHEM, Randal Robert; SHAVER, Jeremy Martin; CLARK, Rutilio H.; TAYLOR, John Alex
United States Patent Application: 20220230710
PDF of patent application.
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Anti-HIV Antibody 10-1074 Variants
Filing Date: 2019-09-12
Publication Date: 2022-04-21
Inventors: Nussenzweig, Michel; Ketchem, Randal R.; Siska, Christine C.; Gillespie, Alison J.; Clark, Rutilio H.; Kerwin, Bruce A.
United States Patent Application: 20220119504
PDF of patent application.
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VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
Filing Date: 2021-10-01
Publication Date: 2022-02-24
Inventors: O'NEILL, Jason C.; KETCHEM, Randal R.; LEE, TaeWeon; CHINTALGATTU, Vishnu; STEVENS, Jennitte LeAnn
United States Patent Application: 20220089689
PDF of patent application.
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VARIANTS OF TISSUE INHIBITOR OR METALLOPROTIENASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
Filing Date: 2015-08-26
Publication Date: 2018-02-01
Inventors: O'Neill, Jason C.; Ketchem, Randal R.; Lee, Taeweon; Chintalgattu, Vishnu; Stevens, Jennitte Leann
United States Patent Application: 20180030116
PDF of patent application.
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HUMAN IL-23 ANTIGEN BINDING PROTEINS
Filing Date: 2021-11-12
Publication Date: 2022-02-24
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randel R.
United States Patent Application: 20220056122
PDF of patent application.
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Human IL-23 Antigen Binding Proteins
Filing Date: 2021-04-13
Publication Date: 2021-07-29
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20210230267
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HUMAN IL-23 ANTIGEN BINDING PROTEINS
Filing Date: 2020-10-01
Publication Date: 2021-01-28
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20210024626
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Human IL-23 Antigen Binding Proteins
Filing Date: 2020-02-08
Publication Date: 2020-06-11
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20200181255
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HUMAN IL-23 ANTIGEN BINDING PROTEINS
Filing Date: 2019-06-26
Publication Date: 2019-10-24
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20190322737
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Human IL-23 Antigen Binding Proteins
Filing Date: 2018-11-19
Publication Date: 2019-03-07
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20190071498
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HUMAN IL-23 ANTIGEN BINDING PROTEINS
Filing Date: 2016-09-21
Publication Date: 2017-01-05
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20170002070
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HUMAN IL-23 ANTIGEN BINDING PROTEINS
Filing Date: 2014-03-28
Publication Date: 2014-07-31
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20140212428
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HUMAN IL-23 ANTIGEN BINDING PROTEINS
Filing Date: 2010-10-26
Publication Date: 2013-01-03
Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
United States Patent Application: 20130004501
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ANTIBODY THERAPIES FOR HUMAN IMMUNODEFICIENCY VIRUS (HIV)
Filing Date: 2019-11-19
Publication Date: 2022-01-27
Inventors: BAROUCH, Dan H.; KERWIN, Bruce A.; KETCHEM, Randal R.; GILLESPIE, Alison J.; SISKA, Christine C.; CLARK, Rutilio H.; FLOYD, Julee A.; SHAVER, Jeremy M.
United States Patent Application: 20220025021
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ANTIBODY THERAPIES FOR HUMAN IMMUNODEFICIENCY VIRUS (HIV)
Filing Date: 2019-05-22
Publication Date: 2021-07-08
Inventors: BAROUCH, Dan H.; KERWIN, Bruce A.; KETCHEM, Randal R.; GILLESPIE, Alison J.; SISKA, Christine C.; CLARK, Rutilio H.; FLOYD, Julee A.; SHAVER, Jeremy M.; ROGERS, Richard S.
United States Patent Application: 20210206838
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INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
Filing Date: 2016-05-04
Publication Date: 2021-05-13
Inventors: BUTZ, Eric Alan; THOMSON, Christy Ann; GAVIN, Marc Alain; FOLTZ, Ian Nevin; XIA, Dong; ALCORN, Dina N.; KETCHEM, Randal Robert; LIM, Ai Ching; MANCHULENKO, Kathy; SEKIROV, Laura; BERRY, Kelly Ann; DE IMUS, Cyr Clovis Chua; AGRAWAL, Neeraj Jagdish; KANNAN, Gunasekaran; LI, Li
United States Patent Application: 20210139554
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INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
Filing Date: 2016-05-04
Publication Date: 2020-01-23
Inventors: BUTZ, Eric Alan; THOMSON, Christy Ann; GAVIN, Marc Alain; FOLTZ, Ian Nevin; XIA, Dong; ALCORN, Dina N.; LIM, Ai Ching; KETCHEM, Randal Robert; MANCHULENKO, Kathy; SEKIROV, Laura; BERRY, Kelly Ann; DE IMUS, Cyr Clovis Chua; AGRAWAL, Neeraj Jagdish; KANNAN, Gunasekaran; LI, Li
United States Patent Application: 20200024319
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DETERMINING PROTEIN STRUCTURE AND PROPERTIES BASED ON SEQUENCE
Filing Date: 2019-02-26
Publication Date: 2021-02-11
Inventors: Amimeur, Tileli; Shaver, Jeremy Martin; Ketchem, Randal Robert
United States Patent Application: 20210043272
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DETERMINING CONDITIONS FOR PURIFICATION OF PROTEINS
Filing Date: 2019-02-21
Publication Date: 2020-12-31
Inventors: SHAVER, Jeremy Martin; AMIMEUR, Tileli; GILLESPIE, Ron; KETCHEM, Randal R.; GARCIA, Fernando
United States Patent Application: 20200408728
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PREDICTING MOLECULAR PROPERTIES OF MOLECULAR VARIANTS USING RESIDUE-SPECIFIC MOLECULAR STRUCTURAL
FEATURES
Filing Date: 2018-06-08
Publication Date: 2020-05-07
Inventors: Shaver, Jeremy Martin; Ketchem, Randal Robert
United States Patent Application: 20200143904
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DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMINE SYNTHETASE
INTRAGENIC COMPLEMENTATION VECTORS
Filing Date: 2017-05-11
Publication Date: 2019-05-02
Inventors: KETCHEM, Randal Robert; MCGREW, Jeffrey T.; FOMINA YADLIN, Dina A.; MUNRO, Trent P.; AGRAWAL, Neeraj Jagdish; DARIS, Kristine M.
United States Patent Application: 20190127452
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VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
Filing Date: 2018-12-04
Publication Date: 2019-03-21
Inventors: Sun, Jeonghoon; O'Neill, Jason Charles; Ketchem, Randal R.; Hecht, Randy Ira; Belouski, Edward J.; Michaels, Mark Leo
United States Patent Application: 20190085054
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VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
Filing Date: 2014-03-13
Publication Date: 2016-02-04
Inventors: Sun, Jeonghoon; O'Neill, Jason Charles; Ketchem, Randal R.; Hecht, Randy Ira; Belouski, Edward J.; Michaels, Mark Leo
United States Patent Application: 20160031969
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GITR ANTIGEN BINDING PROTEINS
Filing Date: 2016-10-10
Publication Date: 2017-01-26
Inventors: Beers, Courtney; O'Neill, Jason C.; Foltz, Ian; Ketchem, Randal R.; Piasecki, Julia C.
United States Patent Application: 20170022285
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GITR ANTIGEN BINDING PROTEINS
Filing Date: 2014-08-28
Publication Date: 2015-03-05
Inventors: Beers, Courtney; O'Neill, Jason C.; Foltz, Ian; Ketchem, Randal R.; Piasecki, Julia C.
United States Patent Application: 20150064204
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HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
Filing Date: 2014-03-14
Publication Date: 2016-02-04
Inventors: Michaels, Mark Leo; Ketchem, Randal R.; Piper, Derek E.; Yan, Wei; King, Chadwick Terence; Howard, Monique LaRae
United States Patent Application: 20160032014
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2014-12-05
Publication Date: 2015-03-26
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20150087819
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2014-09-16
Publication Date: 2015-01-29
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent Application: 20150031870
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NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
(PCSK9)
Filing Date: 2014-08-14
Publication Date: 2014-12-04
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140357854
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NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
(PCSK9)
Filing Date: 2014-08-14
Publication Date: 2014-12-04
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140357853
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NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
(PCSK9)
Filing Date: 2014-08-14
Publication Date: 2014-12-04
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140357852
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NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
(PCSK9)
Filing Date: 2014-08-14
Publication Date: 2014-12-04
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140357851
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NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
(PCSK9)
Filing Date: 2014-08-14
Publication Date: 2014-12-04
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140357850
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2014-04-24
Publication Date: 2014-08-21
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent Application: 20140235831
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2014-04-24
Publication Date: 2014-08-21
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent Application: 20140235830
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2014-04-24
Publication Date: 2014-08-14
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140228557
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2014-04-24
Publication Date: 2014-08-14
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140228547
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2014-04-24
Publication Date: 2014-08-14
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20140228545
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2013-04-10
Publication Date: 2013-09-19
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
United States Patent Application: 20130245235
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2012-03-16
Publication Date: 2013-04-04
inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20130085265
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2012-03-16
Publication Date: 2013-03-28
inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinto; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20130079501
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2012-10-19
Publication Date: 2013-03-07
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20130058944
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2012-10-19
Publication Date: 2013-02-28
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20130052201
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2012-06-12
Publication Date: 2012-10-04
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20120251544
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2012-05-03
Publication Date: 2012-08-23
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20120213797
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2011-06-30
Publication Date: 2012-04-19
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20120093818
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2011-10-03
Publication Date: 2012-02-02
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20120027765
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2011-10-03
Publication Date: 2012-01-26
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20120020976
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2011-10-03
Publication Date: 2012-01-26
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20120020975
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2010-10-12
Publication Date: 2011-02-03
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20110027287
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2008-08-22
Publication Date: 2009-06-04
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20090142352
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IL-1 FAMILY VARIANTS
Filing Date: 2016-01-22
Publication Date: 2016-05-19
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
United States Patent Application: 20160137708
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IL-1 FAMILY VARIANTS
Filing Date: 2014-09-22
Publication Date: 2015-01-15
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
United States Patent Application: 20150017123
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IL-1 FAMILY VARIANTS
Filing Date: 2013-06-11
Publication Date: 2013-12-19
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem; Randal R.
United States Patent Application: 20130336926
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IL-1 FAMILY VARIANTS
Filing Date: 2007-09-10
Publication Date: 2012-01-26
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
United States Patent Application: 20120020918
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IL-1 family variants
Filing Date: 2007-09-10
Publication Date: 2008-10-02
Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
United States Patent Application: 20080241096
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VARIANT FC-POLYPEPTIDES WITH ENHANCED BINDING TO THE NEONATAL FC RECEPTOR
Filing Date: 2012-12-17
Publication Date: 2014-12-04
Inventors: Sun, Jeonghoon; Han, Seog Joon; Harris, Susie M.; Ketchem, Randal R; Lu, Ji; Michaels, Mark L; Retter, Marc W; Tsai, Mei-Mei
United States Patent Application: 20140356358
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VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
Filing Date: 2014-03-12
Publication Date: 2014-09-18
Inventors: Ketchem, Randal R.; O'Neill, Jason Charles; Sun, Jeonghoon
United States Patent Application: 20140274874
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ST2 ANTIGEN BINDING PROTEINS
Filing Date: 2021-06-04
Publication Date: 2022-04-21
Inventors: SMITH, Dirk E.; FOLTZ, Ian; KING, Chadwick T.; LIM, Ai Ching; CLARK, Rutilio; COMEAU, Michael R.; KETCHEM, Randal R.; SHI, Donghui; MIN, Xiaoshan; WANG, Zhulun
United States Patent Application: 20220119537
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ST2 ANTIGEN BINDING PROTEINS
Filing Date: 2019-01-08
Publication Date: 2019-11-28
Inventors: R.FOLTZ, Ian; KING, Chadwick T.; LIM, Ai Ching; CLARK, Rutilio; COMEAU, Michael R.; KETCHEM, Randal R.; SHI, Donghui; MIN, Xiaoshan; WANG, Zhulun
United States Patent Application: 20190359720
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ST2 ANTIGEN BINDING PROTEINS
Filing Date: 2017-05-22
Publication Date: 2017-09-21
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent Application: 20170267769
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ST2 ANTIGEN BINDING PROTEINS
Filing Date: 2016-06-10
Publication Date: 2017-01-05
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent Application: 20170002079
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ST2 ANTIGEN BINDING PROTEINS
Filing Date: 2013-05-17
Publication Date: 2014-01-02
Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
United States Patent Application: 20140004107
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POLYPEPTIDES AND ANTIBODIES
Filing Date: 2012-09-07
Publication Date: 2013-04-25
Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
United States Patent Application: 20130101589
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Polypeptides and Antibodies
Filing Date: 2009-04-02
Publication Date: 2009-09-10
Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
United States Patent Application: 20090226438
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Polypeptides and antibodies
Filing Date: 2006-08-28
Publication Date: 2007-08-02
Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
United States Patent Application: 20070179086
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ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
Filing Date: 2012-09-14
Publication Date: 2013-03-21
Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terrence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
United States Patent Application: 20130072665
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ANTI-HEPCIDIN ANTIBODIES AND METHODS OF USE
Filing Date: 2009-04-28
Publication Date: 2011-06-23
Inventors: Foltz, Ian; Gallo, Michael; Cooke, Keegan; Ketchem, Randal R.; Mehlin, Christopher
United States Patent Application: 20110150888
PDF of patent application.
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TWEAK Receptor
Filing Date: 2010-10-06
Publication Date: 2011-01-27
Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow III, William C.
United States Patent Application: 20110020267
PDF of patent application.
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TWEAK RECEPTOR
Filing Date: 2009-01-16
Publication Date: 2009-05-28
Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.
United States Patent Application: 20090137036
PDF of patent application.
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TWEAK receptor
Filing Date: 2004-10-22
Publication Date: 2005-09-22
Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III
United States Patent Application: 20050208046
PDF of patent application.
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Erythropoietin receptor agonists
Filing Date: 2007-04-13
Publication Date: 2008-05-29
Inventors: Borges, Luis G.; Ketchem, Randal R.; Lim, Ai Ching; Mehlin, Christopher; Zhou, Hongxing
United States Patent Application: 20080124340
PDF of patent application.
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Cytokine polypeptides
Filing Date: 2006-11-20
Publication Date: 2007-04-12
Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.; Taylor, Scott L.
United States Patent Application: 20070081973
PDF of patent application.
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Cytokine polypeptides
Filing Date: 2002-05-08
Publication Date: 2003-06-05
Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.; Taylor, Scott L.
United States Patent Application: 20030104579
PDF of patent application.
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Human cytokine and alpha-helix-containing polypeptides
Filing Date: 2006-12-06
Publication Date: 2007-03-29
Inventors: Baum, Peter R.; Ketchem, Randal R.; DuBose, Robert F.; Wiley, Steven R.; Kerkof, Keith N.
United States Patent Application: 20070072249
PDF of patent application.
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Human and murine cytokine polypeptides
Filing Date: 2005-07-07
Publication Date: 2006-05-25
Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.
United States Patent Application: 20060110772
PDF of patent application.
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Human and murine cytokine polypeptides
Filing Date: 2002-10-02
Publication Date: 2003-07-17
Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.
United States Patent Application: 20030134306
PDF of patent application.
Invited Talks
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AI-Derived Antibody Discovery – Humanoid Fab and VHH Biotherapeutics for Global Good
Antibody Engineering and Therapeutics
2022-12-07
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Improving Biotherapeutic Development Through Structured Data Utilization
Antibody Engineering and Therapeutics
2018-12-13
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Improving Biotherapeutic Development Through AI Technologies
AI Pharma Innovation Drug Discovery
2018-02-27
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Structured Data Driven Approaches Toward Reducing the Cost of Biotherapeutics
2017 Grand Challenges Meeting
2017-10-03
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Computational Design and High Throughput Characterization to Predict and Repair Molecular Attributes
Protein Engineering Summit (PEGS) 2017
2017-05-04
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Therapeutic Antibody Designs for Efficacy and Manufacturability
LabKey User Group Meeting 2016
Recorded talk
2016-10-06
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Antibody and Protein Engineering: Developing Therapeutics
FSU Kasha Award Seminar
2014-04-15
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Antibody Optimization Before the Storm
PepTalk 2013
2013-01-23
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Mitigation of Monoclonal Antibody Viscosity by Modification of Protein Surface Charge
Protein Engineering Summit (PEGS) 2012
2012-04-30
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Mediating Antibody Viscosity
Chemical Computing Group User Group Meeting
2010-06-03
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Pacific Lutheran University
Mining the Human Genome Using Protein Structure Homology
2002-09-11
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Western Washington University
Mining the Human Genome Using Protein Structure Homology
2002-06-05
Ph.D. Dissertation
Structural Determination and Refinement of the Gramicidin A Transmembrane Channel as Studied by Solid State Nuclear Magnetic Resonance Spectroscopy
Randal R. Ketchem
ISBN: 9798208130704.
PDF Version.Photography
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Title: Sperry Peak, Fresh Snow
Image ID: d20071201115356
Image on RRKPhoto.com
Outdoor Photographer, Favorite Places, November, 2011
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Title:Sunrise on Sea Stacks, Reflected, Oceanside, Oregon
Image ID: d20060721011
Image on RRKPhoto.com
Outdoor Photographer, 2009 Calendar
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Title: Fall Color on Coal Lake #7
Image ID: d20041002011
Image on RRKPhoto.com
Outdoor Photographer, Favorite Places, March, 2006
Education
Ph.D. Molecular Biophysics
Florida State University | Tallahassee, FL | 1989-08 - 1995-12
Ph.D. in Molecular Biophysics at the Florida State University and National High Magnetic Field Laboratory working on Solid State Nuclear Magnetic Resonance Spectroscopy and computational methods for the structure determination of the Gramicidin A transmembrane channel.
Advisor Timothy A. Cross.
B.S. Chemistry/Biochemistry
University of West Florida | Pensacola, FL | 1987-08 - 1989-08
While obtaining my B.S. in Chemistry I worked in the research lab of Dr. John Riehm, performing protein purification using gel columns and HPLC, and performing solid phase peptide synthesis.
A.A.
Okaloosa Walton Junior College | Niceville, FL | 1983-06 - 1987-08
For my AA I focused on Biology and general science, taking courses across the spectrum of the sciences including Chemistry, Biology and Physics.
Employment History
Ketchem Biotherapeutics Consulting LLC
Shalimar, FL
2025-01 - Present
Providing expert guidance for biotherapeutic discovery and molecular design.
Just - Evotec Biologics
Seattle, WA
Senior Vice President of Biotherapeutic Discovery and Molecular Design
2021-05 - 2024-12
Encompassing discovery, design, analysis, and evaluation of biologics-based therapeutics.
Just Biotherapeutics
Seattle, WA
Vice President of Molecular Design
2014-11 - 2021-05
Molecular Design encompasses all design, analysis, and evaluation of biologics-based therapeutics.
Amgen Inc
Seattle, WA
Director of Research
2011-01 - 2014-11
Led the Protein and Antibody Optimization team, responsible for engineering all biologics that come through Amgen's pipeline. My research direction is focused on computational structural biology while also applying my skills to broader platform review and direction. Working in areas of antibody design, epitope mapping, molecular assessment, stability engineering, construct design, protein engineering and serving on therapeutic area teams to lead target development.
Amgen Inc
Seattle, WA
Principal Scientist
2002-07 - 2011-01
My move to Amgen was due to Immunex being purchased by Amgen. My research direction is focused on computational structural biology while also applying my skills to broader platform review and direction. Working in areas of antibody epitope mapping, molecular assessment, stability engineering, construct design, protein engineering and serving on therapeutic area teams to lead target development.
Immunex Corporation
Seattle, WA
Scientist
1997-11 - 2002-07
Computational structural biology involving protein structure determination, analysis and design, protein target discovery, and protein engineering.
The Scripps Research Institute
La Jolla, CA
Postdoctoral Fellow
1996-02 - 1997-11
Postdoctoral research in Molecular Biology at The Scripps Research Institute working on High Resolution Nuclear Magnetic Resonance Spectroscopy and computational methods for the structure determination of calcium loaded calcyclin and small molecule binders to the minor groove of DNA.
The Florida State University
Tallahassee, FL
Postdoctoral Fellow
1995-12 - 1996-02
Continued as a Postdoctoral Fellow under my Ph.D. advisor, Timothy A. Cross.
Hobbies
Photography (Randal R. Ketchem Photography)References
Available on request -
Implementing A Generative Machine Learning Architecture To Produce Training Data For A Classification
Model